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Article

Impact of T161, Y318 and S363 alanine mutations on regulation of the human delta-opioid receptor (hDOPr) induced by peptidic and alkaloid agonists.

Neuropharmacology - 15 Nov 2020

Camacho Elise, Marie Nicolas, Dupas Quentin, Martel Caroline, Nowoczyn Marie, Elie Nicolas, Rochais Christophe, Töth Geza, Allouche Stéphane

Abstract excerpt

Previously, we showed a differential regulation of the human delta-opioid receptor (hDOPr) by etorphine and [D-Pen2, D-Pen5] enkephalin (DPDPE). To understand the molecular basis of such differences, we introduced 3 alanine mutations at the residues T161. Y318 and S363. Both wild type (WT) and hDOPr mutants were expressed in HEK cells containing endogenous arrestins or CFP-tagged arrestin 3, then desensitization,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32841607
DOI: 10.1016/j.neuropharm.2020.108286

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