Article
Mutation S363A in the human delta-opioid receptor selectively reduces down-regulation by a peptide agonist.
European journal of pharmacology - 6 Feb 2004
Navratilova Edita, Varga Eva V, Stropova Dagmar, Jambrosic Janelle C, Roeske William R, Yamamura Henry I
Abstract excerpt
Chemically distinct opioid agonists have different abilities to down-regulate opioid receptors. The present study investigated the role of Ser(363) in human delta-opioid receptor down-regulation by a delta-selective peptide- and non-peptide agonist. Cyclic[D-Pen(2),D-Pen(5)]enkephalin (DPDPE)-mediated down-regulation was significantly attenuated by a S363A mutation. In contrast, this mutation had no effect on...
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