Article
Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.
Journal of biomedical science - 1 Jan 2005
Chang Liang-Chen, Huang Chi-Hui, Cheng Chi-Hung, Chen Bor-Huah, Chen Hong-Chen
Abstract excerpt
Upon cell adhesion to extracellular matrix proteins, focal adhesion kinase (FAK) rapidly undergoes autophosphorylation on its Tyr-397 which consequently serves as a binding site for the Src homology 2 domains of the Src family protein kinases and several other intracellular signaling molecules. In this study, we have attempted to examine the effect of the FAK Y397F mutant on v-Src-stimulated cell transformation...
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