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Article

Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration.

The Journal of biological chemistry - 30 Apr 1999

Reiske H R, Kao S C, Cary L A, Guan J L, Lai J F, Chen H C

Abstract excerpt

We have previously shown that overexpression of focal adhesion kinase (FAK) in Chinese hamster ovary (CHO) cells promoted their migration on fibronectin. This effect was dependent on the phosphorylation of FAK at Tyr-397. This residue was known to serve as a binding site for both Src and phosphatidylinositol 3-kinase (PI3K), implying that either one or both are required for FAK to promote cell migration. In this...

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PMID: 10212207
DOI: 10.1074/jbc.274.18.12361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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