Article
Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis.
Cancer letters - 8 Nov 2008
Kaneda Tomonori, Sonoda Yoshiko, Ando Kumi, Suzuki Takaharu, Sasaki Yasuhiro, Oshio Tomoyuki, Tago Megumi, Kasahara Tadashi
Abstract excerpt
This study focused on the role of focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase important for many cellular processes, in the proliferation, adhesion, and invasion of melanoma cells in vitro and in vivo. We found that the Y925F-mutation of FAK in B16F10 melanoma cells suppressed metastasis in an experimental model, which correlated well with decreased extracellular matrix dependent proliferative...
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