Article
Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407.
The Journal of biological chemistry - 6 Apr 2007
Lim Yangmi, Park Haein, Jeon Jihyun, Han Innoc, Kim Jinsook, Jho Eek-Hoon, Oh Eok-Soo
Abstract excerpt
Focal adhesion kinase (FAK) mediates signal transduction in response to multiple extracellular inputs via tyrosine phosphorylation at specific residues. Although several tyrosine phosphorylation events have been linked to FAK activation and downstream signal transduction, the function of FAK phosphorylation at Tyr(407) was previously unknown. Here, we show for the first time that phosphorylation of FAK Tyr(407)...
Topics
- Animals
- Cell Adhesion
- Cell Movement
- Cell Proliferation
- Enzyme Activation
- Focal Adhesion Kinase 1
- Mice
- Mutation
- NIH 3T3 Cells
- Phosphorylation
- Protein Processing, Post-Translational
- Signal Transduction
- Tyrosine