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Article

Library versus library recognition and inhibition of the HIV-1 Nef allelome.

Journal of the American Chemical Society - 7 Sept 2005

Olszewski Allison, Weiss Gregory A

Abstract excerpt

Rapid evolution of drug-resistant viruses renders essentially all small-molecule antiviral treatments ineffective. We demonstrate an in vitro library versus library approach to identify small molecules targeting a broad spectrum of HIV-1 Nef protein variants. The technique could provide more effective antiviral therapies. First, a library of clinically derived Nef allelic variants, termed an allelome, was...

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Identifiers

PMID: 16131168
DOI: 10.1021/ja053316l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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