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Article

Human immunodeficiency virus type 1 entry inhibitors selected on living cells from a library of phage chemokines.

Journal of virology - 1 Jun 2003

Hartley Oliver, Dorgham Karim, Perez-Bercoff Danielle, Cerini Fabrice, Heimann Anouk, Gaertner Hubert, Offord Robin E, Pancino Gianfranco, Debré Patrice, Gorochov Guy

Abstract excerpt

The chemokine receptors CCR5 and CXCR4 are promising non-virus-encoded targets for human immunodeficiency virus (HIV) therapy. We describe a selection procedure to isolate mutant forms of RANTES (CCL5) with antiviral activity considerably in excess of that of the native chemokine. The phage-displayed library of randomly mutated and N-terminally extended variants was screened by using live CCR5-expressing cells,...

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Share to Anti-HIV Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CCR5

Source

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Identifiers

PMID: 12767983
DOI: 10.1128/jvi.77.12.6637-6644.2003
PMCID: PMC156188

Genes

CCR5
CCL5
CCR1
CCR3
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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