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DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges

14 Jun 2021

Abstract excerpt

DNA-encoded chemical libraries (DELs) represent a versatile and powerful technology platform for the discovery of small-molecule ligands to protein targets of biological and pharmaceutical interest. DELs are collections of molecules, individually coupled to distinctive DNA tags serving as amplifiable identification barcodes. Thanks to advances in DNA-compatible reactions, selection methodologies, next-generation...

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PMID: 34423264
DOI: 10.1021/acsptsci.1c00118

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