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Article

Characterisation of aptamer-target interactions by branched selection and high-throughput sequencing of SELEX pools.

Nucleic acids research - 2 Dec 2015

Dupont Daniel M, Larsen Niels, Jensen Jan K, Andreasen Peter A, Kjems Jørgen

Abstract excerpt

Nucleic acid aptamer selection by systematic evolution of ligands by exponential enrichment (SELEX) has shown great promise for use in the development of research tools, therapeutics and diagnostics. Typically, aptamers are identified from libraries containing up to 10(16) different RNA or DNA sequences by 5-10 rounds of affinity selection towards a target of interest. Such library screenings can result in...

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PMID: 26163061
DOI: 10.1093/nar/gkv700
PMCID: PMC4666376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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