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DIVERSITY OF OLIGONUCLEOTIDE FUNCTIONS

1 Jun 1995

Abstract excerpt

SELEX is a technology for the identification of high affinity oligonucleotide ligands. Large libraries of random sequence single-stranded oligonucleotides, whether RNA or DNA, can be thought of conformationally not as short strings but rather as sequence dependent folded structures with high degrees of molecular rigidity in solution. This conformational complexity means that such a library is a source of high...

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PMID: 7574500
DOI: 10.1146/annurev.bi.64.070195.003555

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