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Article

Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56 <sup>lck</sup>

15 Sept 2004

Abstract excerpt

With current anti-HIV treatments targeting only 4 of the 15 HIV proteins, many potential viral vulnerabilities remain unexploited. We report small-molecule inhibitors of the HIV-1 protein Nef. In addition to expanding the anti-HIV arsenal, small-molecule inhibitors against untargeted HIV proteins could be used to dissect key events in the HIV lifecycle. Numerous incompletely characterized interactions between Nef...

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PMID: 15371598
DOI: 10.1073/pnas.0406040101

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