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Article

Encoded library technology screening of hepatitis C virus NS4B yields a small-molecule compound series with in vitro replicon activity.

Antimicrobial agents and chemotherapy - 1 Jan 2015

Arico-Muendel Christopher, Zhu Zhengrong, Dickson Hamilton, Parks Derek, Keicher Jesse, Deng Jianghe, Aquilani Leah, Coppo Frank, Graybill Todd, Lind Kenneth, Peat Andrew, Thomson Michael

Abstract excerpt

To identify novel antivirals to the hepatitis C virus (HCV) NS4B protein, we utilized encoded library technology (ELT), which enables purified proteins not amenable to standard biochemical screening methods to be tested against large combinatorial libraries in a short period of time. We tested NS...

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Identifiers

PMID: 25824229
DOI: 10.1128/AAC.00070-15
PMCID: PMC4432136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25824229-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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