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Article

Discovery of Selective Inhibitors Against EBNA1 via High Throughput In Silico Virtual Screening

12 Apr 2010

Abstract excerpt

BACKGROUND: Epstein-Barr Virus (EBV) latent infection is associated with several human malignancies and is a causal agent of lymphoproliferative diseases during immunosuppression. While inhibitors of herpesvirus DNA polymerases, like gancyclovir, reduce EBV lytic cycle infection, these treatments have limited efficacy for treating latent infection. EBNA1 is an EBV-encoded DNA-binding protein required for viral...

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PMID: 20405039
DOI: 10.1371/journal.pone.0010126

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