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Article

Central IL-1 receptor signaling regulates bone growth and mass.

Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005

Bajayo Alon, Goshen Inbal, Feldman Sharon, Csernus Valer, Iverfeldt Kerstin, Shohami Esther, Yirmiya Raz, Bab Itai

Abstract excerpt

The proinflammatory cytokine IL-1, acting via the hypothalamic IL-1 receptor type 1 (IL-1RI), activates pathways known to suppress bone formation such as the hypothalamo pituitary-adrenocortical axis and the sympathetic nervous system. In addition, peripheral IL-1 has been implicated as a mediator of the bone loss induced by sex hormone depletion and TNF. Here, we report an unexpected low bone mass (LBM)...

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Source

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Identifiers

PMID: 16126903
DOI: 10.1073/pnas.0502562102
PMCID: PMC1200265

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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