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Article

Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation.

Genes & development - 15 Aug 2003

Kim Sunhwa, Koga Takako, Isobe Miho, Kern Britt E, Yokochi Taeko, Chin Y Eugene, Karsenty Gerard, Taniguchi Tadatsugu, Takayanagi Hiroshi

Abstract excerpt

Bone remodeling is central to maintaining the integrity of the skeletal system, wherein the developed bone is constantly renewed by the balanced action of osteoblastic bone formation and osteoclastic bone resorption. In the present study, we demonstrate a novel function of the Stat1 transcription factor in the regulation of bone remodeling. In the bone of the Stat1-deficient mice, excessive osteoclastogenesis is...

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Identifiers

PMID: 12923053
DOI: 10.1101/gad.1119303
PMCID: PMC196253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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