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Article

Overexpression of the human interleukin 1a gene causes osteopenia in mice.

The Journal of rheumatology - 1 Feb 2005

Aoki Yoshihiro, Ichimura Shoichi, Kikuchi Toshiyuki, Yoshihara Yasuo, Kogawa Masakazu, Tada Norihiro, Nemoto Koichi, Fujikawa Kyosuke

Abstract excerpt

OBJECTIVE: Osteoporosis is a major complication of chronic inflammatory diseases such as rheumatoid arthritis (RA). We describe disordered bone metabolism in transgenic mice that overexpress human interleukin 1a (hIL-1a). METHODS: Bone mineral density (BMD), microcomputed tomography (microCT), histomorphometry, and blood biochemical data of hIL-1a transgenic mice and littermate wild-type mice were examined....

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Source

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PMID: 15693094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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