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Article

Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse.

Developmental biology - 1 Oct 2005

Wijgerde Mark, Karp Seth, McMahon Jill, McMahon Andrew P

Abstract excerpt

The interaction between bone morphogenetic proteins (BMPs) and their antagonist, Noggin, is critical for normal development. Noggin null mice die at birth with a severely malformed skeleton that is postulated to reflect the activity of unopposed BMP signaling. However, the widespread expression and redundancy of different BMPs have made it difficult to identify a specific role for individual BMPs during mammalian...

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Source

Identifiers

PMID: 16122729
DOI: 10.1016/j.ydbio.2005.07.016

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse.PMID 16122729Read ↗

Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning.Semantic proximity Read ↗

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Smad6 is essential to limit BMP signaling during cartilage developmentSemantic proximity Read ↗

The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth.Semantic proximity Read ↗

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis.Semantic proximity Read ↗

Bone Morphogenetic Protein Signals Are Required for Cartilage Formation and Differently Regulate Joint Development During SkeletogenesisSemantic proximity Read ↗

Noggin is required for first pharyngeal arch differentiation in the frog Xenopus tropicalis.Semantic proximity Read ↗

Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN.Semantic proximity Read ↗

Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.Semantic proximity Read ↗

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