Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.

Science (New York, N.Y.) - 29 May 1998

Brunet L J, McMahon J A, McMahon A P, Harland R M

Abstract excerpt

Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs. In mice lacking Noggin, cartilage condensations initiated normally but developed hyperplasia, and initiation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Gene Expression
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Morphogenesis

Share to Mutation

Share to Proteins

Source

Identifiers

PMID: 9603738
DOI: 10.1126/science.280.5368.1455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9603738-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.PMID 9603738Read ↗

The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defectsSemantic proximity Read ↗

Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse.Semantic proximity Read ↗

Bone Morphogenetic Protein Signals Are Required for Cartilage Formation and Differently Regulate Joint Development During SkeletogenesisSemantic proximity Read ↗

Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning.Semantic proximity Read ↗

Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN.Semantic proximity Read ↗

Genetic control of bone and joint formation.Semantic proximity Read ↗

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis.Semantic proximity Read ↗

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo.Semantic proximity Read ↗

The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis.Semantic proximity Read ↗

Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family.Semantic proximity Read ↗

The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth.Semantic proximity Read ↗

MicroRNA-92a Upholds Bmp Signaling by Targeting noggin3 during Pharyngeal Cartilage FormationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.