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Article

Noggin is required for first pharyngeal arch differentiation in the frog Xenopus tropicalis.

Developmental biology - 15 Jun 2017

Young John J, Kjolby Rachel A S, Wu Gloria, Wong Daniel, Hsu Shu-Wei, Harland Richard M

Abstract excerpt

The dorsal ventral axis of vertebrates requires high BMP activity for ventral development and inhibition of BMP activity for dorsal development. Presumptive dorsal regions of the embryo are protected from the ventralizing activity of BMPs by the secretion of BMP antagonists from the mesoderm. Noggin, one such antagonist, binds BMP ligands and prevents them from binding their receptors, however, a unique role for...

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Identifiers

PMID: 27364468
DOI: 10.1016/j.ydbio.2016.06.034
PMCID: PMC5209299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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