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Article

Smad6 is essential to limit BMP signaling during cartilage development

16 Jun 2011

Abstract excerpt

Bone morphogenetic protein (BMP) signaling pathways regulate multiple aspects of endochondral bone formation. The importance of extracellular antagonists as regulators of BMP signaling has been defined. In vitro studies reveal that the intracellular regulators, inhibitory Smads 6 and 7, can regulate BMP-mediated effects on chondrocytes. Although in vivo studies in which inhibitory Smads were overexpressed in...

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PMID: 21681813
DOI: 10.1002/jbmr.443

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