Article
Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis.
Nature genetics - 1 Mar 1999
Gong Y, Krakow D, Marcelino J, Wilkin D, Chitayat D, Babul-Hirji R, Hudgins L, Cremers C W, Cremers F P, Brunner H G, Reinker K, Rimoin D L, Cohn D H, Goodman F R, Reardon W, Patton M, Francomano C A, Warman M L
Abstract excerpt
The secreted polypeptide noggin (encoded by the Nog gene) binds and inactivates members of the transforming growth factor beta superfamily of signalling proteins (TGFbeta-FMs), such as BMP4 (ref. 1). By diffusing through extracellular matrices more efficiently than TGFbeta-FMs, noggin may have a principal role in creating morphogenic gradients. During mouse embryogenesis, Nog is expressed at multiple sites,...
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