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Article

Patterning the zebrafish axial skeleton requires early chordin function.

Nature genetics - 1 Dec 1999

Fisher S, Halpern M E

Abstract excerpt

Members of the bone morphogenetic protein (BMP) family actively promote ventral cell fates, such as epidermis and blood, in the vertebrate gastrula. More dorsally, the organizer region counteracts BMP signalling through secretion of BMP-binding antagonists chordin and noggin, allowing dorsally derived tissues such as neurectoderm and somitic muscle to develop. BMPs also function in skeletal development and...

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Identifiers

PMID: 10581032
DOI: 10.1038/70557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patterning the zebrafish axial skeleton requires early chordin function.PMID 10581032Read ↗

The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.Semantic proximity Read ↗

Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse.Semantic proximity Read ↗

Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning.Semantic proximity Read ↗

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.Semantic proximity Read ↗

Short- and long-range functions of Goosecoid in zebrafish axis formation are independent of Chordin, Noggin 1 and Follistatin-like 1b.Semantic proximity Read ↗

Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning.Semantic proximity Read ↗

Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes.Semantic proximity Read ↗

An ancient chordin-like gene in organizer formation of Hydra.Semantic proximity Read ↗

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.Semantic proximity Read ↗

Noggin is required for first pharyngeal arch differentiation in the frog Xenopus tropicalis.Semantic proximity Read ↗

Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos.Semantic proximity Read ↗

WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation.Semantic proximity Read ↗

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