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Article

Therapeutic targeting of BAG3: considering its complexity in cancer and heart disease.

The Journal of clinical investigation - 16 Aug 2021

Kirk Jonathan A, Cheung Joseph Y, Feldman Arthur M

Abstract excerpt

Bcl2-associated athanogene-3 (BAG3) is expressed ubiquitously in humans, but its levels are highest in the heart, the skeletal muscle, and the central nervous system; it is also elevated in many cancers. BAG3's diverse functions are supported by its multiple protein-protein binding domains, which couple with small and large heat shock proteins, members of the Bcl2 family, other antiapoptotic proteins, and various...

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Identifiers

PMID: 34396980
DOI: 10.1172/JCI149415
PMCID: PMC8363278

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