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Article

Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium

18 Aug 2005

Abstract excerpt

Several described growth factors influence the proliferation and regeneration of the intestinal epithelium. Using a transgenic mouse model, we identified a human gene, R-spondin1, with potent and specific proliferative effects on intestinal crypt cells. Human R-spondin1 (hRSpo1) is a thrombospondin domain-containing protein expressed in enteroendocrine cells as well as in epithelial cells in various tissues. Upon...

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PMID: 16109882
DOI: 10.1126/science.1112521

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