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Tissue-targeted R-spondin mimetics for liver regeneration

18 Aug 2020

Abstract excerpt

R-spondin (RSPO) proteins amplify Wnt signaling and stimulate regeneration in a variety of tissues. To repair tissue in a tissue-specific manner, tissue-targeted RSPO mimetic molecules are desired. Here, we mutated RSPO (RSPO2 F105R/F109A) to eliminate LGR binding while preserving ZNRF3/RNF43 binding and targeted the mutated RSPO to a liver specific receptor, ASGR1. The resulting bi-specific molecule...

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PMID: 32811902
DOI: 10.1038/s41598-020-70912-3

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