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Article

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations.

Blood - 1 Dec 2005

Döhner Konstanze, Schlenk Richard F, Habdank Marianne, Scholl Claudia, Rücker Frank G, Corbacioglu Andrea, Bullinger Lars, Fröhling Stefan, Döhner Hartmut

Abstract excerpt

To assess the prognostic relevance of mutations in the NPM1 gene encoding a nucleocytoplasmic shuttle protein in younger adults with acute myeloid leukemia (AML) and normal cytogenetics, sequencing of NPM1 exon 12 was performed in diagnostic samples from 300 patients entered into 2 consecutive multicenter trials of the AML Study Group (AMLSG). Treatment included intensive double-induction therapy and...

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Source

Identifiers

PMID: 16051734
DOI: 10.1182/blood-2005-05-2164

Genes

NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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