Article
[Studies on fermentation conditions and purification of mutant human interleukin-2 expressed in Pichia pastoris].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 May 2005
Liu Yan, Su Chang, Hu Ying-He, Ouyang Ke-Qing, Cai Shao-Xi
Abstract excerpt
Interleukin-2 (IL-2) was initially isolated as a T cell growth factor and had been shown to direct the expansion and differentiation of several hematopoietic cell types. Clinical studies using IL-2 in the treatment of AIDS have been encouraging, due to its critical role as a proliferative signal for activated T-lymphocytes. IL-2 has also undergone trials in the treatment of several types of cancer, based on its...
Topics
- Fermentation
- Humans
- Interleukin-2
- Mutant Proteins
- Mutation
- Pichia
- Protein Engineering
- Recombinant Proteins