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Article

Sex Differences in Cortical Thickness and Neuropsychiatric Symptom Burden Based on APOE4 Homozygosity in Alzheimer's Disease.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2025

Khoury Marc A, Valcic Mila, Churchill Nathan W, Di Battista Alex, De Luca Vincenzo, Fornazzari Luis R, Munoz David G, Fischer Corinne E, Schweizer Tom A

Abstract excerpt

Sex differences in patterns of cortical thickness and neuropsychiatric symptom (NPS) burden were examined among individuals with Alzheimer's disease (AD) and two copies (homozygote carriers) of the e4 allele of the apolipoprotein gene (APOE). A total of 752 participants with a clinical etiologic diagnosis of AD were selected from the National Alzheimer's Coordinating Center (NACC) database. Bayesian multilevel...

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Identifiers

PMID: 39350506
DOI: 10.1002/ajmg.b.33008

Genes

NPS
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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