Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic predisposition to 4NQO-induced tongue carcinogenesis in the rat.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre - 1 Jan 2000

Tanuma Jun-ichi, Hirano Masato, Hirayama Yoshikazu, Semba Ichiro, Ogawa Kotaro, Shisa Hayase, Hiai Hiroshi, Kitano Motoo

Abstract excerpt

OBJECTIVE: This study aims to elucidate the genetic basis of predisposition to 4-nitroquinoline 1-oxide (4NQO)-induced tongue cancers (TCs). MATERIALS AND METHODS: We have reported that inbred Dark-Agouti (DA) strain rats were highly susceptible to 4NQO-induced TCs, whereas Wistar/Furth (WF) rats were resistant to tongue squamous cell carcinomas induced by oral administration of 4NQO. Using size and number of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 4-Nitroquinoline-1-oxide
Share to Carcinogens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Loss of Heterozygosity

Share to Models, Animal

Share to Multifactorial Inheritance

Share to Tongue Neoplasms

Source

Identifiers

PMID: 16103694
DOI: 10.1159/000086926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic predisposition to 4NQO-induced tongue carcinogenesis in the rat.PMID 16103694Read ↗

Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat.Semantic proximity Read ↗

A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats.Semantic proximity Read ↗

Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis.Semantic proximity Read ↗

Selective loss of resistant alleles at p15INK4B and p16INK4A genes in chemically-induced rat tongue cancers.Semantic proximity Read ↗

Host genes controlling the susceptibility and resistance to squamous cell carcinoma of the tongue in a rat model.Semantic proximity Read ↗

Carcinogenesis modifier loci in rat tongue are subject to frequent loss of heterozygosity.Semantic proximity Read ↗

Frequent mutation of p16(CDKN2A) exon 1 during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.Semantic proximity Read ↗

p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer.Semantic proximity Read ↗

Systems genetics analysis of oral squamous cell carcinoma susceptibility using the mouse model: current position and new perspective.Semantic proximity Read ↗

No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.Semantic proximity Read ↗

The role of the TP53 gene during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.Semantic proximity Read ↗

A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.