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Article

No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.

Journal of molecular histology - 1 Feb 2009

Minicucci Eliana Maria, da Silva Glenda Nicioli, Ribeiro Daniel Araki, Favero Salvadori Daisy Maria

Abstract excerpt

The medium-term tongue carcinogenesis assay is a useful model for studying oral squamous cell carcinomas phase by phase. The present study aimed to investigate mutations in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide (4NQO) using direct DNA-sequencing method. A total of 30 male Wistar rats were treated with 4-nitroquinoline 1-oxide (4NQO) in drinking water for 4,...

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Identifiers

PMID: 19255859
DOI: 10.1007/s10735-009-9215-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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