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Article

A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.

International journal of experimental pathology - 1 Feb 2020

Tan Melody T, Wu Jean G, Callejas-Valera Juan Luis, Schwarz Richard A, Gillenwater Ann M, Richards-Kortum Rebecca R, Vigneswaran Nadarajah

Abstract excerpt

Oral cancer causes significant global mortality and has a five-year survival rate of around 64%. Poor prognosis results from late-stage diagnosis, highlighting an important need to develop better approaches to detect oral premalignant lesions (OPLs) and identify which OPLs are at highest risk of progression to oral squamous cell carcinoma (OSCC). An appropriate animal model that reflects the genetic, histologic,...

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Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred CBA

Share to Oncogene Proteins, Viral

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Source

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Identifiers

PMID: 32436348
DOI: 10.1111/iep.12347
PMCID: PMC7306900

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