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Article

A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats.

Cancer letters - 18 Jan 2006

Hirano Masato, Tanuma Jun-Ichi, Hirayama Yoshikazu, Ohyama Masanobu, Semba Ichiro, Wakusawa Shinya, Shisa Hayase, Hiai Hiroshi, Kitano Motoo

Abstract excerpt

We previously reported that Dark-Agouti (DA) rats are highly susceptible to 4-nitroquinoline 1-oxide (4NQO)-induced tongue cancer (TC), whereas Wistar/Furth (WF) rats are barely susceptible. Linkage analysis of reciprocal (DAxWF)F2 rats demonstrated five quantitative trait loci, Tongue squamous cell carcinoma 1-5 (Tscc1-5) determining the size and number of the TCs. The major susceptibility locus Tscc1 is mapped...

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Source

Identifiers

PMID: 15876484
DOI: 10.1016/j.canlet.2005.01.043

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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