Article
Carcinogenesis modifier loci in rat tongue are subject to frequent loss of heterozygosity.
International journal of cancer - 20 Dec 2002
Tanuma Jun-ichi, Hiai Hiroshi, Shisa Hayase, Hirano Masato, Semba Ichiro, Nagaoka Shigetaka, Kitano Motoo
Abstract excerpt
Rats of the DA strain are highly susceptible to 4NQO-induced TCs, whereas WF rats are barely susceptible. In (DA x WF)F2 rats, 5 QTL, Tscc1-5, are responsible for most of the phenotypic variations, though they do not account for all of the phenotypic differences between WF and DA rats. Analysis o...
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