Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse genetics.

doi:10.1128/JVI.01227-12

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Article

Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse genetics.

Journal of virology - 1 Oct 2012

Luongo Cindy, Winter Christine C, Collins Peter L, Buchholz Ursula J

Abstract excerpt

Human respiratory syncytial virus (RSV) is the most important viral cause of serious pediatric respiratory illness worldwide. Currently, the most promising live-attenuated vaccine candidate is a temperature-sensitive (ts) cDNA-derived virus named rA2cp248/404/1030ΔSH, in reference to its set of attenuating mutations. In a previous clinical study, more than one-third of postvaccination nasal wash isolates...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
Codon
DNA, Complementary
Female
Humans
Mice
Mice, Inbred BALB C
Models, Genetic
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Mutation, Missense

Open Reading Frames

Pan troglodytes

Phenotype

Respiratory Syncytial Virus Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 22837193
DOI: 10.1128/JVI.01227-12
PMCID: PMC3457269

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