Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse genetics.

Journal of virology - 1 Oct 2012

Luongo Cindy, Winter Christine C, Collins Peter L, Buchholz Ursula J

Abstract excerpt

Human respiratory syncytial virus (RSV) is the most important viral cause of serious pediatric respiratory illness worldwide. Currently, the most promising live-attenuated vaccine candidate is a temperature-sensitive (ts) cDNA-derived virus named rA2cp248/404/1030ΔSH, in reference to its set of attenuating mutations. In a previous clinical study, more than one-third of postvaccination nasal wash isolates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon
Share to DNA, Complementary
Share to Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Open Reading Frames

Share to Pan troglodytes

Share to Respiratory Syncytial Virus Infections

Share to Respiratory Syncytial Viruses

Share to Vaccines, Attenuated

Source

Open in PubMed Open full text

Identifiers

PMID: 22837193
DOI: 10.1128/JVI.01227-12
PMCID: PMC3457269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse genetics.PMID 22837193Read ↗

Respiratory Syncytial Virus Modified by Deletions of the NS2 Gene and Amino Acid S1313 of the L Polymerase Protein Is a Temperature-Sensitive, Live-Attenuated Vaccine Candidate That Is Phenotypically Stable at Physiological TemperatureSemantic proximity Read ↗

The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein.Semantic proximity Read ↗

Live Respiratory Syncytial Virus (RSV) Vaccine Candidate Containing Stabilized Temperature-Sensitivity Mutations Is Highly Attenuated in RSV-Seronegative Infants and Children.Semantic proximity Read ↗

A single nucleotide substitution in the transcription start signal of the M2 gene of respiratory syncytial virus vaccine candidate cpts248/404 is the major determinant of the temperature-sensitive and attenuation phenotypes.Semantic proximity Read ↗

Addition of a Missense Mutation Present in the L Gene of Respiratory Syncytial Virus (RSV)cpts530/1030 to RSV Vaccine Candidatecpts248/404 Increases Its Attenuation and Temperature SensitivitySemantic proximity Read ↗

Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure.Semantic proximity Read ↗

Genetic stability determinants of temperature sensitive, live attenuated respiratory syncytial virus vaccine candidates.Semantic proximity Read ↗

Nucleotide sequence analysis of the respiratory syncytial virus subgroup A cold-passaged (cp) temperature sensitive (ts) cpts-248/404 live attenuated virus vaccine candidate.Semantic proximity Read ↗

Nonclinical phenotypic and genotypic analyses of a Phase 1 pediatric respiratory syncytial virus vaccine candidate MEDI-559 (rA2cp248/404/1030ΔSH) at permissive and non-permissive temperatures.Semantic proximity Read ↗

The two amino acid substitutions in the L protein of cpts530/1009, a live-attenuated respiratory syncytial virus candidate vaccine, are independent temperature-sensitive and attenuation mutations.Semantic proximity Read ↗

Acquisition of the ts phenotype by a chemically mutagenized cold-passaged human respiratory syncytial virus vaccine candidate results from the acquisition of a single mutation in the polymerase (L) gene.Semantic proximity Read ↗

New generation live vaccines against human respiratory syncytial virus designed by reverse genetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.