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Article

Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.

Nature cell biology - 1 Aug 2005

Naga Prasad Sathyamangla V, Jayatilleke Arundathi, Madamanchi Aasakiran, Rockman Howard A

Abstract excerpt

Phosphoinositide 3-kinase (PI(3)K) is a unique enzyme characterized by both lipid and protein kinase activities. Here, we demonstrate a requirement for the protein kinase activity of PI(3)K in agonist-dependent beta-adrenergic receptor (betaAR) internalization. Using PI(3)K mutants with either protein or lipid phosphorylation activity, we identify the cytoskeletal protein non-muscle tropomyosin as a substrate of...

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PMID: 16094730
DOI: 10.1038/ncb1278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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