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Article

Differential phosphorylation of the phosphoinositide 3-phosphatase MTMR2 regulates its association with early endosomal subtypes.

Journal of cell science - 15 Mar 2013

Franklin Norah E, Bonham Christopher A, Xhabija Besa, Vacratsis Panayiotis O

Abstract excerpt

Myotubularin-related 2 (MTMR2) is a 3-phosphoinositide lipid phosphatase with specificity towards the D-3 position of phosphoinositol 3-phosphate [PI(3)P] and phosphoinositol 3,5-bisphosphate lipids enriched on endosomal structures. Recently, we have shown that phosphorylation of MTMR2 on Ser58 is responsible for its cytoplasmic sequestration and that a phosphorylation-deficient variant (S58A) targets MTMR2 to...

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Share to Endosomes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Protein Tyrosine Phosphatases, Non-Receptor

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Source

Identifiers

PMID: 23378027
DOI: 10.1242/jcs.113928

Genes

MTMR2
APPL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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