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Article

Immunoprecipitation and phosphorylation of G protein-coupled receptors.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009

Thomas Walter G

Abstract excerpt

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven transmembrane-spanning alpha-helices. Following ligand activation, many GPCRs are rapidly phosphorylated on serine/threonine residues in their cytoplasmic domains, principally the carboxyl-terminus. GPCR phosphorylation recruits arrestin proteins to the activated receptor leading to receptor internalization and desensitization....

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PMID: 19513663
DOI: 10.1007/978-1-60327-317-6_26

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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