Article
The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch.
Cellular signalling - 1 Nov 2009
Dhillon Amardeep S, Yip Yan Yan, Grindlay G Joan, Pakay Julian L, Dangers Marc, Hillmann Meike, Clark William, Pitt Andrew, Mischak Harald, Kolch Walter
Abstract excerpt
The Raf-1 protein kinase is a major activator of the ERK MAPK pathway, which links signaling by a variety of cell surface receptors to the regulation of cell proliferation, survival, differentiation and migration. Signaling by Raf-1 is regulated by a complex and poorly understood interplay between phosphorylation events and protein-protein interactions. One important mode of Raf-1 regulation involves the...
Topics
- 14-3-3 Proteins
- Amino Acid Substitution
- Animals
- Binding Sites
- COS Cells
- Cell Line
- Chlorocebus aethiops
- Extracellular Signal-Regulated MAP Kinases
- Humans
- MAP Kinase Kinase Kinases
- Mice
- Mutation
- Phosphorylation