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Article

The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch.

Cellular signalling - 1 Nov 2009

Dhillon Amardeep S, Yip Yan Yan, Grindlay G Joan, Pakay Julian L, Dangers Marc, Hillmann Meike, Clark William, Pitt Andrew, Mischak Harald, Kolch Walter

Abstract excerpt

The Raf-1 protein kinase is a major activator of the ERK MAPK pathway, which links signaling by a variety of cell surface receptors to the regulation of cell proliferation, survival, differentiation and migration. Signaling by Raf-1 is regulated by a complex and poorly understood interplay between phosphorylation events and protein-protein interactions. One important mode of Raf-1 regulation involves the...

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Identifiers

PMID: 19595761
DOI: 10.1016/j.cellsig.2009.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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