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Article

Biological impacts of "hot-spot" mutations of hepatitis B virus X proteins are genotype B and C differentiated.

World journal of gastroenterology - 14 Aug 2005

Lin Xu, Xu Xiao, Huang Qing-Ling, Liu Yu-Qing, Zheng Da-Li, Chen Wan-Nan, Lin Jian-Yin

Abstract excerpt

AIM: To investigate the biological impacts of "hot-spot" mutations on genotype B and C HBV X proteins (HBx). METHODS: Five types of "hot-spot" mutations of genotype B or C HBV X genes, which sequentially lead to the amino acid substitutions of HBx as I127T, F132Y, K130M+V131I, I127T+K130M+V131I, or K130M+V131I+F132Y, respectively, were generated by means of site-directed mutagenesis. To evaluate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16094714
DOI: 10.3748/wjg.v11.i30.4703
PMCID: PMC4615415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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