Article
X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy.
Virus research - 15 Oct 2017
Elizalde María Mercedes, Campos Rodolfo Héctor, Barbini Luciana
Abstract excerpt
The hepatitis B virus X protein (HBV-X) is a multifunctional regulatory protein associated with the pathogenesis of liver disease in chronic HBV infection. Basal core promoter mutations (BCP), associated with the clinical course of chronic HBV infection, affect HBV-X at 130-131 positions. The rol...
Topics
- Apoptosis
- Autophagy
- Cell Line, Tumor
- Genotype
- Hepatitis B virus
- Hepatocytes
- Host-Pathogen Interactions
- Humans
- Mutant Proteins
- Proto-Oncogene Proteins c-bcl-2
- Trans-Activators
- Viral Regulatory and Accessory Proteins
- bcl-2-Associated X Protein
- bcl-X Protein