Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy.

Virus research - 15 Oct 2017

Elizalde María Mercedes, Campos Rodolfo Héctor, Barbini Luciana

Abstract excerpt

The hepatitis B virus X protein (HBV-X) is a multifunctional regulatory protein associated with the pathogenesis of liver disease in chronic HBV infection. Basal core promoter mutations (BCP), associated with the clinical course of chronic HBV infection, affect HBV-X at 130-131 positions. The role of these mutations on HBV-X biological activity remains largely unknown. The aim of this study was to analyze the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Hepatitis B virus

Share to Mutant Proteins

Share to Proto-Oncogene Proteins c-bcl-2

Share to Trans-Activators

Share to Viral Regulatory and Accessory Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28986109
DOI: 10.1016/j.virusres.2017.09.025
PMCID: PMC7114566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy.PMID 28986109Read ↗

Hepatitis B virus X protein (HBx)-induced apoptosis in HuH-7 cells: influence of HBV genotype and basal core promoter mutations.Semantic proximity Read ↗

The oncogenic role of hepatitis B virus X gene in hepatocarcinogenesis: recent updatesSemantic proximity Read ↗

Hepatitis B virus-induced hepatocellular carcinoma: The role of the virus x proteinSemantic proximity Read ↗

Human hepatocytes apoptosis induced by replication of hepatitis B virus subgenotypes F1b and F4: Role of basal core promoter and preCore mutations.Semantic proximity Read ↗

X region mutations of hepatitis B virus related to clinical severity.Semantic proximity Read ↗

Modulation of Apoptotic Signaling by the Hepatitis B Virus X ProteinSemantic proximity Read ↗

Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene.Semantic proximity Read ↗

Pathogenesis of hepatitis B virus infection.Semantic proximity Read ↗

Hepatitis B virus X gene and hepatocarcinogenesis.Semantic proximity Read ↗

Hepatitis B virus X protein inhibits nucleotide excision repairSemantic proximity Read ↗

Hepatitis B virus X gene is implicated in liver carcinogenesis.Semantic proximity Read ↗

Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.