Article
Polymorphisms in RET and its coreceptors and ligands as genetic modifiers of multiple endocrine neoplasia type 2A.
Cancer research - 15 Jan 2006
Lesueur Fabienne, Cebrian Arancha, Robledo Mercedes, Niccoli-Sire Patricia, Svensson Karl-Axel, Pinson Stephane, Leyland Jean, Whittaker Joanne, Pharoah Paul D, Ponder Bruce A J
Abstract excerpt
Germ line missense mutations in the RET proto-oncogene are responsible for the inherited cancer syndrome multiple endocrine neoplasia type 2A (MEN2A). The clinical presentation of the disease and the age at onset varies even within families, where patients carry the same mutation. These variations in phenotypes suggest a role for genetic modifiers, and recently, it has been reported that polymorphisms within RET...
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