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Article

Four decades of the RET gene: From discovery to tumor-agnostic therapy

20 Jun 2025

Abstract excerpt

The physiological and disease-related roles of the Rearranged during Transfection (RET) gene have been extensively studied since its discovery four decades ago. RET encodes a receptor tyrosine kinase whose ligands are members of the glial cell line-derived neurotrophic factor (GDNF) family. Unlike other receptor tyrosine kinase ligands, GDNF family ligands (GFLs) do not bind to RET directly; instead, RET requires...

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PMID: 40544107
DOI: 10.1016/j.jfma.2025.06.033

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