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Article

RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.

Cancer research - 1 Mar 2005

Plaza Menacho Ivan, Koster Roelof, van der Sloot Almer M, Quax Wim J, Osinga Jan, van der Sluis Tineke, Hollema Harry, Burzynski Grzegorz M, Gimm Oliver, Buys Charles H C M, Eggen Bart J L, Hofstra Robert M W

Abstract excerpt

The RET proto-oncogene encodes a receptor tyrosine kinase whose dysfunction plays a crucial role in the development of several neural crest disorders. Distinct activating RET mutations cause multiple endocrine neoplasia type 2A (MEN2A), type 2B (MEN2B), and familial medullary thyroid carcinoma (FMTC). Despite clear correlations between the mutations found in these cancer syndromes and their phenotypes, the...

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Share to Carcinoma, Medullary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15753368
DOI: 10.1158/0008-5472.CAN-04-2363

Genes

RET
STAT3
JAK1
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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