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LRRK2 mutations are not common in Alzheimer's disease.

Mechanisms of ageing and development - 1 Nov 2005

Toft Mathias, Sando Sigrid Botne, Melquist Stacey, Ross Owen A, White Linda R, Aasly Jan O, Farrer Matthew J

Abstract excerpt

The development of common age-related neurodegenerative disorders as Parkinson's disease and Alzheimer's disease (AD) are influenced by genetic factors. Recently, pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified in familial Parkinsonism. Individuals in some of these families developed symptoms of dementia with Lewy-bodies and AD. The LRRK2 gene is also located within a...

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Share to Chromosomes, Human, Pair 12

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 16087219
DOI: 10.1016/j.mad.2005.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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