Article
Clinical features of LRRK2-associated Parkinson's disease in central Norway.
Annals of neurology - 1 May 2005
Aasly Jan O, Toft Mathias, Fernandez-Mata Ignacio, Kachergus Jennifer, Hulihan Mary, White Linda R, Farrer Matthew
Abstract excerpt
Several pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2; PARK8) gene recently have been identified in familial and sporadic parkinsonism. We screened 435 Norwegian patients diagnosed with Parkinson's disease and 519 control subjects for the presence of 7 LRRK2 mutations. Nine patients from seven families were found to be heterozygote carriers of the LRRK2 6055G>A (G2019S) mutation. Twelve of 28...
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