Article
Clinical features of LRRK2-associated Parkinson's disease in central Norway.
Annals of neurology - 1 May 2005
Aasly Jan O, Toft Mathias, Fernandez-Mata Ignacio, Kachergus Jennifer, Hulihan Mary, White Linda R, Farrer Matthew
Abstract excerpt
Several pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2; PARK8) gene recently have been identified in familial and sporadic parkinsonism. We screened 435 Norwegian patients diagnosed with Parkinson's disease and 519 control subjects for the presence of 7 LRRK2 mutations. Nine pati...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Antiparkinson Agents
- Female
- Heterozygote
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Levodopa
- Male
- Middle Aged
- Muscle Rigidity
- Mutation
- Norway
- Parkinson Disease
- Pedigree
- Protein Serine-Threonine Kinases