Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway.

doi:10.1016/j.neulet.2007.02.020

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Article

Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway.

Neuroscience letters - 18 Apr 2007

Haugarvoll Kristoffer, Toft Mathias, Ross Owen A, White Linda R, Aasly Jan O, Farrer Matthew J

Abstract excerpt

The discovery of LRRK2 gene mutations in late-onset Parkinson's disease (PD) has irrevocably established the role of genetics in the etiology of PD. The LRRK1 gene is the single homolog of LRRK2. A high degree of homology exists between LRRK1 and LRRK2, indicative of shared functions and/or pathways. One study has examined LRRK1 in familial parkinsonism by complete sequencing of the gene, reporting 4 novel...

Topics

Adult
Aged
Aged, 80 and over
Case-Control Studies
DNA Mutational Analysis
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Glutamic Acid
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lysine

Male

Middle Aged

Norway

Parkinson Disease

Polymorphism, Genetic

Protein Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 17324517
DOI: 10.1016/j.neulet.2007.02.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17324517-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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