Article
Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway.
Neuroscience letters - 18 Apr 2007
Haugarvoll Kristoffer, Toft Mathias, Ross Owen A, White Linda R, Aasly Jan O, Farrer Matthew J
Abstract excerpt
The discovery of LRRK2 gene mutations in late-onset Parkinson's disease (PD) has irrevocably established the role of genetics in the etiology of PD. The LRRK1 gene is the single homolog of LRRK2. A high degree of homology exists between LRRK1 and LRRK2, indicative of shared functions and/or pathways. One study has examined LRRK1 in familial parkinsonism by complete sequencing of the gene, reporting 4 novel...
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