Article
Common variants of LRRK2 are not associated with sporadic Parkinson's disease.
Annals of neurology - 1 Dec 2005
Biskup Saskia, Mueller Jakob C, Sharma Manu, Lichtner Peter, Zimprich Alexander, Berg Daniela, Wüllner Ullrich, Illig Thomas, Meitinger Thomas, Gasser Thomas
Abstract excerpt
Multiple mutations in the gene for the leucine-rich repeat kinase (LRRK2) cause autosomal dominant late-onset parkinsonism (PARK8). The Gly2019Ser mutation appears to be common in different populations. To investigate whether this novel gene influences the non-Mendelian sporadic form of Parkinson...
Topics
- Age of Onset
- Female
- Genetic Predisposition to Disease
- Genotype
- Germany
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Parkinson Disease
- Polymorphism, Single Nucleotide