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Article

Common variants of LRRK2 are not associated with sporadic Parkinson's disease.

Annals of neurology - 1 Dec 2005

Biskup Saskia, Mueller Jakob C, Sharma Manu, Lichtner Peter, Zimprich Alexander, Berg Daniela, Wüllner Ullrich, Illig Thomas, Meitinger Thomas, Gasser Thomas

Abstract excerpt

Multiple mutations in the gene for the leucine-rich repeat kinase (LRRK2) cause autosomal dominant late-onset parkinsonism (PARK8). The Gly2019Ser mutation appears to be common in different populations. To investigate whether this novel gene influences the non-Mendelian sporadic form of Parkinson's disease, we genotyped 121 single nucleotide polymorphisms comprehensively covering the entire LRRK2 gene region in a...

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PMID: 16254973
DOI: 10.1002/ana.20664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Common variants of LRRK2 are not associated with sporadic Parkinson's disease.PMID 16254973Read ↗

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LRRK2 in Parkinson's disease: genetic and clinical studies from patients.Semantic proximity Read ↗

LRRK2 gene in Parkinson disease: mutation analysis and case control association study.Semantic proximity Read ↗

Low prevalence of most frequent pathogenic variants of six PARK genes in sporadic Parkinson's disease.Semantic proximity Read ↗

LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson's disease.Semantic proximity Read ↗

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.Semantic proximity Read ↗

Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.Semantic proximity Read ↗

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