Article
LRRK2 p.G2019S mutation is not common among Alzheimer's disease patients in Brazil.
Disease markers - 1 Jan 2009
Santos-Rebouças Cíntia Barros, Abdalla Cláudia Bueno, Martins Paloma Aguia, Baldi Fábio José Rodrigues, Santos Jussara Mendonça, Motta Luciana Branco, de Borges Margarete Borges, Souza Dorotéia Rossi Silva, de Souza Pinhel Marcela Augusta, Laks Jerson, Pimentel Márcia Mattos Gonçalves
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have emerged as a potential common cause for both sporadic and familial Parkinson's Disease (PD) in different populations. The pleomorphic features exhibited by LRRK2 mutation carriers and the central role of Lrrk2 protein in the proper functioning of central nervous system suggest that mutations in this protein might be involved in multiple cellular...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Brazil
- DNA
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans