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Article

Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.

Neuroscience letters - 10 Jul 2006

Saunders-Pullman Rachel, Lipton Richard B, Senthil Geetha, Katz Mindy, Costan-Toth Camille, Derby Carol, Bressman Susan, Verghese Joe, Ozelius Laurie J

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 gene (LRRK2) have been associated with idiopathic Parkinson's disease (PD), as well as pleomorphic neurodegenerative pathology, including Alzheimer's disease. One specific LRRK2 mutation, G2019S, was reported in 18% of people with PD of Ashkenazi descent, supporting a founder effect in this population. To determine if this mutation is also associated with dementia in the...

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PMID: 16632201
DOI: 10.1016/j.neulet.2006.03.044

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Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.PMID 16632201Read ↗

The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews.Semantic proximity Read ↗

Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations.Semantic proximity Read ↗

LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.Semantic proximity Read ↗

Glucocerebrosidase mutations are not found in association with LRRK2 G2019S in subjects with parkinsonism.Semantic proximity Read ↗

Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.Semantic proximity Read ↗

The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease: is there a gender effect?Semantic proximity Read ↗

Motor and non-motor features of Parkinson's disease in LRRK2 G2019S carriers versus matched controls.Semantic proximity Read ↗

Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries.Semantic proximity Read ↗

Mutations in the Parkinson's disease genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor.Semantic proximity Read ↗

Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry.Semantic proximity Read ↗

Motor progression of Parkinson's disease with the leucine-rich repeat kinase 2 G2019S mutation.Semantic proximity Read ↗

LRRK2 p.G2019S mutation is not common among Alzheimer's disease patients in Brazil.Semantic proximity Read ↗

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